• Association Between Amygdala Volume and Trajectories of Neuropsychiatric Symptoms in Alzheimer’s Disease and Dementia With Lewy Bodies 

      Jaramillo-Jiménez, Alberto; Melvær, Giil Lasse; Tovar-Rios, Diego Alejandro; Borda, Miguel Germán; Ferreira, Daniel; Brønnick, Kolbjørn Kallesten; Oppedal, Ketil; Aarsland, Dag (Peer reviewed; Journal article, 2021-07)
      Introduction: The amygdala is implicated in psychiatric illness. Even as the amygdala undergoes significant atrophy in mild dementia, amygdala volume is underexplored as a risk factor for neuropsychiatric symptoms ...
    • The combined effect of amyloid-β and tau biomarkers on brain atrophy in dementia with Lewy bodies 

      Abdelnour, Carla; Ferreira, Daniel; Oppedal, Ketil; Cavallin, Lena; Bousiges, Olivier; Wahlund, Lars Olof; Hort, Jakub; Nedelska, Zuzana; Padovani, Alessandro; Pilotto, Andrea; Bonanni, Laura; Kramberger, Milica Gregoric; Boada, Mercè; Westman, Eric; Pagonabarraga, Javier; Kulisevsky, Jaime; Blanc, Frédéric; Aarsland, Dag (Peer reviewed; Journal article, 2020-07)
      Background Alzheimer’s disease (AD)-related pathology is frequently found in patients with dementia with Lewy bodies (DLB). However, it is unknown how amyloid-β and tau-related pathologies influence neurodegeneration in ...
    • MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies 

      Inguanzo, Anna; Poulakis, Konstantinos; Mohanty, Rosaleena; Schwarz, Christopher G.; Przybelski, Scott A.; Diaz-Galvan, Patricia; Lowe, Val J.; Boeve, Bradley F.; Lemstra, Afina W.; van de Beek, Marleen; van der Flier, Wiesje; Barkhof, Frederik; Blanc, Frederic; Loureiro de Sousa, Paulo; Philippi, Nathalie; Cretin, Benjamin; Demuynck, Catherine; Nedelska, Zuzana; Hort, Jakub; Segura, Barbara; Junque, Carme; Oppedal, Ketil; Aarsland, Dag; Westman, Eric; Kantarci, Kejal; Ferreira, Daniel (Peer reviewed; Journal article, 2023)
      Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) ...
    • Parsing heterogeneity within dementia with Lewy bodies using clustering of biological, clinical, and demographic data 

      Abdelnour, Carla; Ferreira, Daniel; van de Beek, Marleen; Cedres, Nira; Oppedal, Ketil; Cavallin, Lena; Blanc, Frédéric; Bousiges, Olivier; Wahlund, Lars-Olof; Pilotto, Andrea; Padovani, Alessandro; Boada, Mercè; Pagonabarraga, Javier; Kulisevsky, Jaime; Aarsland, Dag; Lemstra, Afina W.; Westman, Eric (Peer reviewed; Journal article, 2022)
      Background Dementia with Lewy bodies (DLB) includes various core clinical features that result in different phenotypes. In addition, Alzheimer’s disease (AD) and cerebrovascular pathologies are common in DLB. All this ...
    • The reliability of a deep learning model in clinical out-of-distribution MRI data: A multicohort study 

      Mårtensson, Gustav; Ferreira, Daniel; Granberg, Tobias; Cavallin, Lena; Oppedal, Ketil; Padovani, Alessandro; Rektorova, Irena; Bonanni, Laura (Peer reviewed; Journal article, 2020-12)
      Deep learning (DL) methods have in recent years yielded impressive results in medical imaging, with the potential to function as clinical aid to radiologists. However, DL models in medical imaging are often trained on ...
    • Sex differences in brain atrophy in dementia with Lewy bodies 

      Oltra, Javier; Habich, Annegret; Schwarz, Christopher G.; Nedelska, Zuzana; Przybelski, Scott A.; Inguanzo, Anna; Diaz-Galvan, Patricia; Lowe, Val J.; Oppedal, Ketil; Gonzalez Velez, Maria Camila; Philippi, Nathalie; Blanc, Frederic; Barkhof, Frederik; Lemstra, Afina W.; Hort, Jakub; Padovani, Alessandro; Rektorova, Irena; Bonanni, Laura; Massa, Federico; Kramberger, Milica G.; Taylor, John-Paul; Snædal, Jon G.; Walker, Zuzana; Antonini, Angelo; Dierks, Thomas; Segura, Barbara; Junque, Carme; Westman, Eric; Boeve, Bradley F.; Aarsland, Dag; Kantarci, Kejal; Ferreira, Daniel (Peer reviewed; Journal article, 2023)
      INTRODUCTION Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS We ...
    • Timed Up and Go in People with Subjective Cognitive Decline Is Associated with Faster Cognitive Deterioration and Cortical Thickness 

      Borda, Miguel Germán; Ferreira, Daniel; Selnes, Per; Tovar-Rios, Diego Alejandro; Jaramillo-Jiménez, Alberto; Kirsebom, Bjørn-Eivind; Garcia-Cifuentes, Elkin; Dalaker, Turi Olene; Oppedal, Ketil; Sønnesyn, Hogne; Fladby, Tormod; Aarsland, Dag (Peer reviewed; Journal article, 2022)
      Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the ...
    • Tongue muscle mass is associated with total grey matter and hippocampal volumes in Dementia with Lewy Bodies 

      Borda, Miguel Germán; Castellanos-Perilla, Nicolás; Tovar-Rios, Diego Alejandro; Ferreira, Daniel; Duque, Gustavo; Aarsland, Dag (Peer reviewed; Journal article, 2022-02)
      Background Age-related neurodegeneration, sarcopenia, and ectopic fat accumulation are conditions with shared pathways that remain poorly understood. We have measured muscle volume and fat accumulation in masseter and ...